Journal of endocrinological investigation

The most recent articles from: January 2020

  • J. Endocrinol. Invest. · Jan 2020

    Review

    Copeptin in the differential diagnosis of hypotonic polyuria.

    Copeptin is secreted in equimolar amount to Arginine Vasopressin (AVP) but can easily be measured with a sandwich immunoassay. Both peptides, copeptin and AVP, show a high correlation. Accordingly, copeptin mirrors the amount of AVP in the circulation and its measurement provides an attractive marker in the differential diagnosis of diabetes insipidus. ⋯ Therefore, we propose that copeptin upon hypertonic saline infusion should become the new standard test in the differential diagnosis of diabetes insipidus.

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