Irish journal of medical science
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The aim of this study was to investigate the dynamic characteristics and changing trends of ambulatory blood pressure in patients with hypertension and coronary heart disease before and after percutaneous coronary intervention (PCI), and to determine the effects of PCI on the ambulatory blood pressure of patients with hypertension and coronary heart disease. ⋯ PCI can significantly improve the autonomic nerve function and ambulatory blood pressure indices of patients with hypertension and coronary heart disease.
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Randomized Controlled Trial
Effects on somatosensory and motor evoked potentials of senile patients using different doses of dexmedetomidine during spine surgery.
The aim of this study was to evaluate the effects of different doses of dexmedetomidine (Dex) compounded propofol and fentanyl on intraoperative somatosensory evoked potential (SEP) and motor evoked potential (MEP) monitoring on senile patients. ⋯ Dex did not affect SEPs of senile patients, but inhibited MEPs when larger doses were administered.
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Somatosensory-evoked potentials (SSEPs) are widely used for intraoperative spinal cord monitoring. Although many general anesthetics inhibit SSEPs, etomidate has been reported to boost SSEPs. This clinical study aimed to test whether etomidate doses less than 0.3 mg/kg amplify SSEP monitoring. ⋯ Small doses of etomidate that were less than 0.3 mg/kg had dose-related amplification effects on SSEP monitoring.
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The aim of this study was to measure any incremental costs or savings within the health system associated with the introduction of the new technology, prucalopride, for the management of chronic constipation. ⋯ This study validated the findings of the NICE costing template and suggests that the use of prucalopride for the treatment of chronic constipation in women refractory to laxatives has the potential to reduce secondary care resource use and hence led to cost savings.
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Randomized Controlled Trial
Remifentanil requirements for preventing motor response to skin incision in healthy women anesthetized with combinations of propofol and dexmedetomidine titrated to similar Bispectral Index (BIS) values.
It is unclear whether the sedative, analgesic or sympatholytic effects of adjunctive dexmedetomidine contribute to reduced analgesic requirements in general anesthesia. This study aimed to assess the analgesic effect of dexmedetomidine on intraoperative opioid requirements using body movement as observation indicator at similar BIS-guided sedative depth in propofol anesthesia. ⋯ Propofol and its combination with dexmedetomidine have similar opioid requirements for preventing motor response to skin incision when titrated to similar BIS values. These findings indicate that adjunctive dexmedetomidine for general anesthesia has sedative but no opioid sparing effects.