Irish journal of medical science
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Safeguarding refers to the protection of health and wellbeing and enabling "life free from harm, abuse and neglect" (Safeguarding People 2019). In Ireland, the Health Service Executive (HSE) drafted a revised 2019 policy to replace the original policy on safeguarding adults at risk of abuse. A Safeguarding Committee was founded in Beaumont Hospital, Dublin to prepare for policy implementation and staff training. ⋯ Knowledge and confidence gaps can be addressed in future training. Identifying education gaps will help guide training and policy implementation.
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The (derived) neutrophil-to-lymphocyte ratio (dNLR) is a potential predictive biomarker in the era of checkpoint inhibitors (CPI). An elevated dNLR is associated with worse outcomes across several malignancies. However, there is no clearly defined cut-off in the clinical setting. ⋯ Lower pre-CPI treatment dNLR is associated with improved OS. A decrease in dNLR during treatment confers improved OS.
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Kinesiophobia can be a barrier for physical activity in patients with multiple sclerosis (PwMS) and it can develop as a result of fear and avoidance reactions due to fatigue. However, there is no valid and reliable scale available to assess kinesiophobia due to fatigue in PwMS. ⋯ TSK-F has excellent reliability and moderate-to-good validity in evaluating kinesiophobia and the scale may be a useful outcome measurement for assessment of kinesiophobia due to fatigue in PwMS.
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Observational Study
Laparoscopic paediatric inguinal hernia repair: lessons learned from 102 cases.
Paediatric inguinal hernias (IHs) are common. The first paediatric laparoscopic hernia repair was described by El-Gohary and colleagues in the United Arab Emirates in 1993. Both laparoscopic inguinal hernia repair (LIHR) and open repair still exist concurrently with no consensus on gold standard treatment at present. The purpose of this study was to retrospectively evaluate our initial experience with LIHR in paediatric patients. ⋯ Paediatric LIHR is a safe, feasible and effective procedure that is associated with a short inpatient length of stay, a low recurrence rate and low postoperative complication rate. The technique is versatile and can be used to treat both elective and emergency presentations with IH in a wide age range.
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The human trophoblast cell surface antigen (TROP-2), a transmembrane glycoprotein, has recently been investigated as a valuable marker of thyroid epithelial neoplasms. In this study, we aimed to demonstrate the diagnostic utility of TROP2 in thyroid neoplasms. ⋯ TROP2 was a helpful marker for differentiating PTC, especially in the classic, tall cell, hobnail, and Warthin-like variants, benign and non-neoplastic lesions, and other neoplasms of the thyroid.