The Veterinary record
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The Veterinary record · Aug 1991
Comparative StudyEffects of thiopentone, propofol, alphaxalone-alphadolone, ketamine and xylazine-ketamine on lower oesophageal sphincter pressure and barrier pressure in cats.
The anaesthetic induction agents thiopentone, propofol and alphaxalone-alphadolone were administered to cats intravenously and ketamine and xylazine-ketamine-atropine were administered intramuscularly in order to determine their effects on gastric pressure, lower oesophageal sphincter pressure, and barrier pressure. Manometric measurements were made with a non-perfused catheter tip pressure transducer. ⋯ Despite a higher gastric pressure in the cats anaesthetised with ketamine rather than with the other drugs except propofol, the barrier pressure was also significantly higher in cats anaesthetised with ketamine than in cats anaesthetised with any of the other drugs except xylazine-ketamine-atropine. The risk of gastrooesophageal reflux seemed to be higher with alphaxalone-alphadolone than with thiopentone if the lower oesophageal sphincter pressure and gastric pressure are used as indicators of likely reflux.