The Veterinary record
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The Veterinary record · Dec 2005
Randomized Controlled TrialTarget-controlled infusion of propofol in dogs--evaluation of four targets for induction of anaesthesia.
Four groups of 20 dogs were anaesthetised by means of target-controlled infusions of propofol designed to achieve 2.5 microg/ml, 3.0 microg/ml, 3.5 microg/ml or 4.0 microg/ml of propofol in blood. The dogs' pulse rate and respiratory rate were recorded before premedication and induction, immediately after endotracheal intubation and three and five minutes later (times 0, 3 and 5, respectively), and their arterial blood pressure was recorded oscillometrically just before induction and at times 0, 3 and 5. ⋯ In all the groups there was a significant (P<0.05) decrease in blood pressure between just before induction and the later measurements. Although there were no statistically significant differences between the groups in terms of inducing anaesthesia at a specific target, a target of 3.5 microg/ml appears to ensure a successful induction of anaesthesia without a significant increase in the incidence of apnoea.