Trends in neurosciences
-
Trends in neurosciences · Jul 2009
ReviewNucleocytoplasmic protein shuttling: the direct route in synapse-to-nucleus signaling.
In neurons multiple signaling pathways converge in the nucleus to regulate the expression of genes associated with long-term structural changes of synapto-dendritic input. Of pivotal importance for this type of transcriptional regulation is synapse-to-nucleus communication. ⋯ We discuss the mechanisms involved in their translocation and their role in the control of nuclear gene expression. Finally, we summarize the current thinking regarding the functional implications of nuclear signaling and address open questions in this evolving area of neuroscience.