Sleep
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Randomized Controlled Trial Comparative Study Clinical Trial
A randomized, double-blind clinical trial comparing continuous positive airway pressure with a novel bilevel pressure system for treatment of obstructive sleep apnea syndrome.
To obtain efficacy, objective compliance, and self-assessment data from obstructive sleep apnea syndrome (OSAS) patients treated with continuous positive airway pressure (CPAP) or a novel bilevel (NBL) therapy. ⋯ The NBL appeared to be as effective as CPAP for the treatment of OSAS but offered no advantages in patients receiving first-time therapy for OSAS.
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Randomized Controlled Trial Multicenter Study Clinical Trial
A multicenter, placebo-controlled trial of melatonin for sleep disturbance in Alzheimer's disease.
To determine the safety and efficacy of 2 dose formulations of melatonin for the treatment of insomnia in patients with Alzheimer's disease. ⋯ Based on actigraphy as an objective measure of sleep time, melatonin is not an effective soporific agent in people with Alzheimer's disease.
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The present study explores the clinical utility and sensitivity of actigraphy as an outcome measure in the treatment of chronic insomnia. ⋯ These results suggest that actigraphy is a useful device for measuring treatment response and that it should be used as a complement to sleep-diary evaluation.