Indian journal of pharmacology
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Randomized Controlled Trial
Comparison of medication acceptance of intranasal midazolam administered by parents versus doctors in children - A randomized trial.
The positive effects of midazolam as a premedication in pediatric patients are well documented. Although there are many studies regarding the route and dosage of administration, literature does not have any evidence on the outcome of medication acceptance based on the person administering the drug. ⋯ Intranasal midazolam when given by parents produces better preoperative anxiolysis and easier parental separation as compared with administration by a medical staff.
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Randomized Controlled Trial
Low-dose sodium valproate versus low-dose propranolol in prophylaxis of common migraine headache: A randomized, prospective, parallel, open-label study.
Migraine is the second most common headache disorder. However, prophylactic therapy remains underutilized. ⋯ Both sodium valproate and propranolol significantly reduced frequency, severity, and duration of migraine headache, but propranolol caused significantly greater reduction in the severity of headache compared to sodium valproate. Both the medications were well tolerated and did not result in discontinuation.