Journal of cardiovascular pharmacology
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J. Cardiovasc. Pharmacol. · Jul 1990
Enalaprilat effects renin-angiotensin and adrenergic response to induced hypotension in the rabbit.
The effects of enalaprilat on the renin-angiotensin system and sympathetic nervous system during sodium nitroprusside (SNP)-induced hypotension and halothane anesthesia were studied in three groups of New Zealand white rabbits. Two groups of rabbits (E and EH) were treated with an infusion of enalaprilat at 3.5 micrograms/kg/min i.v. One enalaprilat-treated group (EH) and the third, untreated group (H) received SNP to induce hypotension. ⋯ In group EH, PRA levels rose sharply and remained elevated. Plasma NE and EPI levels increased slightly with a decline in the SNP dose requirement. Group E demonstrated a rise in PRA levels, accompanied by unchanged NE and EPI levels and MAP during the study period.(ABSTRACT TRUNCATED AT 250 WORDS)