Journal of cardiovascular pharmacology
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J. Cardiovasc. Pharmacol. · Aug 2007
Tetramethylpyrazine-eluting stents prevented in-stent restenosis in a porcine model.
Tetramethylpyrazine, a drug originally isolated from the rhizome of Ligusticum walliichi, is an inhibitor of phosphodiesterase and inhibits platelet aggregation and smooth muscle cell proliferation. The effect of the tetramethylpyrazine-eluting stent (TES) on preventing in-stent restenosis was investigated in comparison with control bare metal stents in a porcine coronary stent restenosis model. ⋯ TES inhibited the neointimal hyperplasia and reduced in-stent restenosis in a porcine coronary artery restenosis model.