Digestive diseases and sciences
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Multicenter Study
Helicobacter pylori first-line and rescue treatments in the presence of penicillin allergy.
Helicobacter pylori eradication is a challenge in penicillin allergy. ⋯ In allergic to penicillin patients, a first-line treatment with a bismuth-containing quadruple therapy (PPI-bismuth-tetracycline-metronidazole) seems to be a better option than the triple PPI-clarithromycin-metronidazole regimen. A levofloxacin-based regimen (together with a PPI and clarithromycin) represents a second-line rescue option in the presence of penicillin allergy.