Clinical cardiology
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Clinical cardiology · May 2003
Randomized Controlled Trial Clinical TrialThe prognostic value of QTc interval and QT dispersion following myocardial infarction in patients treated with or without dofetilide.
Acute myocardial infarction (MI) is associated with an increased risk of death, with a 1-year mortality close to 10% in patients discharged from hospital alive. During the first year following MI, close to 50% of deaths are assumed to be due to arrhythmic events. ⋯ In patients with a recent MI, LV dysfunction, and a short baseline QTc interval, dofetilide is associated with significant survival benefit. This benefit is not seen with a longer QTc interval. QT dispersion is not a risk factor in this population.