Journal of ethnopharmacology
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The term "traditional" is well established in European (human) medicine and even appears in recent European regulations on herbal medicinal products connected to a simplified registration. In contrast, a scientific discussion of a Traditional European Veterinary Herbal Medicine is still lacking in spite of a rising interest, in herbal medicine for animals in particular of veterinarians. There is only limited systematic ethnoveterinary research in Europe, with exception of the Mediterranean region, Switzerland and Austria. We conducted a survey on the ethnoveterinary knowledge of farmers in the pre-alpine and alpine regions of the Swiss cantons of Bern and Lucerne. We compared the findings with earlier studies conducted in Switzerland and with recent and past human and veterinary medicinal literature. ⋯ For the treatment of their animals farmers in the pre-alpine and alpine regions of the Swiss cantons of Bern and Lucerne mostly used plants which have a track record as medicinal herbs in Europe over several centuries. Almost half of the plant species had specific veterinary uses for about 120 years and even more for at least 30 years. The majority of the plant species thus fulfill the criteria of "traditional" according to several definitions and even more up to a certain degree the criteria of "traditional use" as defined in European regulations for human medicinal products. Ethnoveterinary research combined with data from historical sources may serve as a sound foundation for the development and definition of a Traditional European Veterinary Herbal Medicine maybe even with regard to the recent discussion about a simplified registration for Traditional Herbal Veterinary Medicinal Products.
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Mistletoe (Viscum album), an evergreen parasitic plant, has been widely used as an oriental phytomedicine to treat diabetes mellitus. However, it is unknown which mistletoe constituent exerts the beneficial effect against the disease. In this study, we examined the hypoglycemic activity of mistletoe and investigated whether the polypeptide viscothionin, purified from mistletoe, was responsible for the activity. ⋯ Our study indicates that the hypoglycemic effect of mistletoe is mediated by its insulinotropic action and α-glucosidase inhibitory activity, and the effect is due to viscothionin, one of the major bioactive constituents of mistletoe.
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Banxia Xiexin Decoction (BXD) is a representative prescription to regulate spleen and stomach in "Treatise on Febrile Diseases", which has been proven effective for the clinical treatment of irritable bowel syndrome (IBS) in the past decades. However, the active principles and molecular mechanisms involved in BXD against IBS are vague yet. ⋯ The study demonstrated that the synergy molecular mechanisms of BXD mainly involved three therapeutic modules including inhibiting inflammatory reaction, maintaining intestinal function and improving psychological regulation via the multicomponent-target interaction networks. It may also provide the promising drug targets and therapeutic agents for the development of new medicines.