Journal of ethnopharmacology
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Mistletoe has been used since ancient times in Europe mostly for medicinal purposes. Since 1917, mistletoe preparations have been applied in cancer therapy and today are the most frequently used complementary medicine in tumor treatment. The main cytotoxic constituents of Viscum album are lectins and viscotoxins. ⋯ The complete mistletoe extract is more potent to inhibit tumor cell proliferation than isolated ML-1 at an equivalent concentration level. Phenolic compounds found in all Iscucin® preparations might contribute to uphold the cytotoxic activity of ML-1 by antioxidative action. However, further studies are necessary to evaluate the role of VT-A and possible synergistic actions to the antiproliferative effect of aqueous mistletoe extracts.
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Sida cordifolia is used commonly in traditional systems of medicine (TSM) and as folk remedies for treating the wounds (both external and internal), infected area, rheumatic disorders, muscular weakness, tuberculosis, heart problems, bronchitis, neurological problems etc. Therefore, in order to authenticate the claims, a mechanism-oriented investigation of the wound healing properties of this plant is essential. ⋯ It was concluded that HF3 can be applied topically in hydrogel form in the case of delayed wound healing caused by the steroidal drug-dexamethasone, aptly justifying its traditional use. Regarding its mechanism of action, our findings report that the potent adaptive response of SCA-treated WT and Δtrx2 strains towards intracellular ROS specifically mitochondrial-ROS confirms its antioxidant potential. Moreover, as SCA was able to rescue the Δtrx2 strains from stress, it can be inferred that it might be able to induce the enzyme thioredoxin-II to restore redox homeostasis. The findings with the conditional mutant ∆trx2 are the first proof linking SCA action related to particular cellular pathways which may be because of the phenols and flavonoids and their synergistic effect.
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The term "traditional" is well established in European (human) medicine and even appears in recent European regulations on herbal medicinal products connected to a simplified registration. In contrast, a scientific discussion of a Traditional European Veterinary Herbal Medicine is still lacking in spite of a rising interest, in herbal medicine for animals in particular of veterinarians. There is only limited systematic ethnoveterinary research in Europe, with exception of the Mediterranean region, Switzerland and Austria. We conducted a survey on the ethnoveterinary knowledge of farmers in the pre-alpine and alpine regions of the Swiss cantons of Bern and Lucerne. We compared the findings with earlier studies conducted in Switzerland and with recent and past human and veterinary medicinal literature. ⋯ For the treatment of their animals farmers in the pre-alpine and alpine regions of the Swiss cantons of Bern and Lucerne mostly used plants which have a track record as medicinal herbs in Europe over several centuries. Almost half of the plant species had specific veterinary uses for about 120 years and even more for at least 30 years. The majority of the plant species thus fulfill the criteria of "traditional" according to several definitions and even more up to a certain degree the criteria of "traditional use" as defined in European regulations for human medicinal products. Ethnoveterinary research combined with data from historical sources may serve as a sound foundation for the development and definition of a Traditional European Veterinary Herbal Medicine maybe even with regard to the recent discussion about a simplified registration for Traditional Herbal Veterinary Medicinal Products.
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Mistletoe (Viscum album), an evergreen parasitic plant, has been widely used as an oriental phytomedicine to treat diabetes mellitus. However, it is unknown which mistletoe constituent exerts the beneficial effect against the disease. In this study, we examined the hypoglycemic activity of mistletoe and investigated whether the polypeptide viscothionin, purified from mistletoe, was responsible for the activity. ⋯ Our study indicates that the hypoglycemic effect of mistletoe is mediated by its insulinotropic action and α-glucosidase inhibitory activity, and the effect is due to viscothionin, one of the major bioactive constituents of mistletoe.
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Banxia Xiexin Decoction (BXD) is a representative prescription to regulate spleen and stomach in "Treatise on Febrile Diseases", which has been proven effective for the clinical treatment of irritable bowel syndrome (IBS) in the past decades. However, the active principles and molecular mechanisms involved in BXD against IBS are vague yet. ⋯ The study demonstrated that the synergy molecular mechanisms of BXD mainly involved three therapeutic modules including inhibiting inflammatory reaction, maintaining intestinal function and improving psychological regulation via the multicomponent-target interaction networks. It may also provide the promising drug targets and therapeutic agents for the development of new medicines.