Canadian journal of psychiatry. Revue canadienne de psychiatrie
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Meta Analysis Comparative Study
A meta-analysis of the efficacy of pregabalin in the treatment of generalized anxiety disorder.
Generalized anxiety disorder (GAD) is a chronic anxiety disorder that leads to significant functional impairment and reduced quality of life. Pregabalin is a novel analogue of the inhibitory neurotransmitter gamma amino butyric acid, which has been proposed as a treatment for a range of conditions including GAD. This study examined the efficacy of pregabalin for GAD across published trials, using a meta-analytic method. ⋯ Pregabalin is an efficacious therapy for GAD, although effect sizes are smaller than those from earlier studies. Limitations and future research directions are discussed.