Japanese journal of clinical oncology
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Jpn. J. Clin. Oncol. · Jul 2005
An evaluation of busulfan pharmacokinetics in patients undergoing hematopoietic stem cell transplantation.
Busulfan (BU) pharmacokinetics (PK) are shown to be highly variable and thus their evaluation is critical for the success of hematopoietic stem cell transplantation (HST) in Caucasians. However, there are no data available for Japanese patients. ⋯ A possible increased risk of RRT associated with high plasma BU concentrations should be kept in mind after oral administration of BU. A prospective trial of adjusting BU doses depending on the BU PK is warranted for Japanese patients.
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Jpn. J. Clin. Oncol. · Jul 2005
Comparative StudyImportance of the initial volume of parotid glands in xerostomia for patients with head and neck cancers treated with IMRT.
Our aim was to evaluate predictors of xerostomia in patients with head and neck cancers treated with intensity-modulated radiation therapy (IMRT). ⋯ Initial volumes of the parotid glands are significantly correlated with the grade of xerostomia in patients treated with IMRT. The volume of the parotid glands decreased significantly during the course of IMRT.