Japanese journal of clinical oncology
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Jpn. J. Clin. Oncol. · Apr 2008
Multicenter Study Clinical TrialOpioid rotation from oral morphine to oral oxycodone in cancer patients with intolerable adverse effects: an open-label trial.
We prospectively investigated the efficacy of opioid rotation from oral morphine to oral oxycodone in cancer patients who had difficulty in continuing oral morphine treatment because of inadequate analgesia and/or intolerable side effects. ⋯ For patients who had difficulty in continuing oral morphine treatment, regardless of renal function, opioid rotation to oral oxycodone may be an effective approach to alleviate intolerable side effects and pain.