Japanese journal of clinical oncology
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Jpn. J. Clin. Oncol. · Jan 2011
Case ReportsEarly detection of 5-FU-induced acute leukoencephalopathy on diffusion-weighted MRI.
A 59-year-old man treated with 5-fluorouracil and cisplatin for advanced oesophageal cancer presented abnormal behaviour and subsequently developed impairment of cognitive function, dysphagia and dysarthria on the fifth day of the treatment. Although brain computed tomography revealed no abnormal findings, brain magnetic resonance imaging using diffusion-weighted imaging clearly revealed the presence of a high signal intensity in the deep white matter of the bilateral cerebral hemispheres, including the corpus callosum symmetrically. A diagnosis of acute leukoencephalopathy was reached based on these findings. ⋯ Improvement in magnetic resonance imaging findings was delayed compared with that of clinical symptoms; however, the high signal intensity detected in the deep white matter had disappeared completely five months after the onset of symptoms. Early detection of drug-induced leukoencephalopathy is important as the clinical symptoms can be reversed by early discontinuation of the causative drug. Diffusion-weighted magnetic resonance imaging is a useful modality for the early detection and definitive diagnosis of this characteristic encephalopathy.
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Jpn. J. Clin. Oncol. · Jan 2011
Case ReportsMultiple calcifying fibrous pseudotumor of the bilateral pleura.
Calcifying fibrous pseudotumor is a rare lesion characterized histologically by hypocellular hyalinized collagenous tissue with calcifications and patchy lymphocytes infiltration. Occurring most often in children and young adults, calcifying fibrous pseudotumor is a clinically benign lesion that can form over a broad anatomic distribution, including in subcutaneous and deep soft tissues, but is rarely found in the pleura. The cause and mechanisms of pathogenesis of calcifying fibrous pseudotumor are unknown. ⋯ We discuss the differential diagnosis with other benign or malignant soft tissue diseases and also review the recent literature on this rare benign entity. Complete resection of all disseminated lesions was possible with followed thoracotomy. Although multiple lesions may prevent the complete resection and calcifying fibrous pseudotumor of the pleura is considered as benign lesion, complete surgical resection of all lesions seems to be the best therapy for calcifying fibrous pseudotumor of the pleura to reduce additional dissemination and local recurrence.
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Jpn. J. Clin. Oncol. · Jan 2011
Editorial Historical ArticleEditorial. 40th Anniversary of the Japanese Journal of Clinical Oncology (JJCO).