Japanese journal of clinical oncology
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Jpn. J. Clin. Oncol. · Aug 2005
Triplet chemotherapy with cisplatin, gemcitabine and vinorelbine for malignant pleural mesothelioma.
The incidence of malignant pleural mesothelioma (MPM) is expected to increase due to delayed control of occupational exposure to asbestos in Japan. We investigated the use of triplet combination chemotherapy with cisplatin (CDDP), gemcitabine (GEM) and vinorelbine (VNR) for the treatment of Japanese patients with MPM. ⋯ Triplet chemotherapy with CDDP, GEM and VNR was thus found to be highly effective for patients with MPM and its toxicity was manageable. A multi-institutional phase II trial is now being planned to establish the effectiveness of this new regimen in chemotherapy-naive patients with MPM.
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Jpn. J. Clin. Oncol. · Jul 2005
An evaluation of busulfan pharmacokinetics in patients undergoing hematopoietic stem cell transplantation.
Busulfan (BU) pharmacokinetics (PK) are shown to be highly variable and thus their evaluation is critical for the success of hematopoietic stem cell transplantation (HST) in Caucasians. However, there are no data available for Japanese patients. ⋯ A possible increased risk of RRT associated with high plasma BU concentrations should be kept in mind after oral administration of BU. A prospective trial of adjusting BU doses depending on the BU PK is warranted for Japanese patients.
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Jpn. J. Clin. Oncol. · Jul 2005
Comparative StudyImportance of the initial volume of parotid glands in xerostomia for patients with head and neck cancers treated with IMRT.
Our aim was to evaluate predictors of xerostomia in patients with head and neck cancers treated with intensity-modulated radiation therapy (IMRT). ⋯ Initial volumes of the parotid glands are significantly correlated with the grade of xerostomia in patients treated with IMRT. The volume of the parotid glands decreased significantly during the course of IMRT.
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Jpn. J. Clin. Oncol. · Jun 2005
Case ReportsCastleman's disease in the left upper retroperitoneal space mimicking an adrenal neoplasm: report of a case and literature review.
Castleman's disease is a rare disorder characterized by benign proliferation of lymphoid tissue. Most cases occur as a mediastinal mass, although extrathoracic involvement including nodal and extranodal locations has been reported. The left suprarenal location of this localized disease may be mistaken for an adrenal tumor. We report a case of a 51-year-old woman with a Castleman's tumor located superomedial to the upper pole of the left kidney that mimicked an adrenal neoplasm.