Molecular immunology
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Molecular immunology · Jan 2019
Clinical TrialEvaluation of Epstein-Barr virus-specific antibodies in Cypriot multiple sclerosis patients.
Multiple Sclerosis (MS) is a chronic, demyelinating, inflammatory disease of the central nervous system (CNS) with a strong autoimmune component. Several genetic and environmental factors have been suggested to contribute in MS. The Epstein-Barr virus (EBV) is one pathogenic candidate proposed to be involved in the onset of MS and/or induction of subsequent exacerbations. ⋯ There was no significant difference in the presence/absence of EA-D IgG between the two groups nor in the corresponding P. I. levels. The results obtained, revealing higher seropositivity of EBNA-1 IgG and VCA IgG in MS patients, seem to concur with previous findings of studies in other countries, thereby further asserting the theory of EBV involvement in MS.