Neurological research
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Neurological research · Jun 2008
Is supratentorial pressure difference clinically relevant? Analysis of 55 consecutive cases by bilateral intracranial pressure monitoring.
The purpose of this study is to explore the possibilities of an early warning system by measuring intracranial pressure differences in order to prevent secondary insults to the injured brain. ⋯ In patients with focal lesions, although more pronounced in focal II group, apparent pressure differences between two hemispheres within the first hours of admission were found. These pressure differences were related to the volume of the intracranial pathology. ICP monitorization from the lesion side is reasonable as an early forewarning procedure and this might prevent the development of secondary insults by providing the exact ICP values of the patients.
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Neurological research · Jun 2008
Modified calcium accumulation after controlled cortical impact under cyclosporin A treatment: a 45Ca autoradiographic study.
As a neuroprotective drug, cyclosporin A (CsA) has been subject of multiple experimental works in traumatic brain injury (TBI) research. It is well known that CsA inhibits calcium (Ca2+) induced mitochondrial permeability transition (mPT). The aim of this study was to investigate the influence of CsA on the alteration of Ca2+ homeostasis after experimental brain injury. ⋯ Post-traumatic 45Ca accumulation is modified under CsA. The crucial neuroprotective effect of CsA might be unrelated to a reduction of post-traumatic Ca2+ accumulation, especially with regard to the importance of Ca2+ as an intracellular messenger governing a large number of cellular functions.