Neurological research
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Neurological research · Jan 2015
Multicenter StudyPreexisting dual antiplatelet treatment increases the risk of post-thrombolysis intracranial hemorrhage in Chinese stroke patients.
Previous studies have shown conflicting results on the use of antiplatelet (AP) agent and its risk of symptomatic intracerebral hemorrhage (sICH) following thrombolysis for acute ischemic stroke. Our study was to explore the safety of intravenous (IV) thrombolysis in Chinese stroke patients who were on AP prior to stroke. ⋯ The risk of developing sICH is low when thrombolysis is given to patients who are on ASA alone. However, there is potential increased risk of sICH if a patient is on dual AP treatment.
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Neurological research · Jan 2015
Alterations in the gray matter volume in transient ischemic attack: a voxel-based morphometry study.
Several studies have emphasized that transient ischemic attack (TIA) patients suffered functional impairments, but whether underlying morphological alterations exist remains unclear. This study aims to detect possible gray matter volume (GMV) alterations in patients with TIA using voxel-based morphometry (VBM) method. ⋯ Transient ischemic attack patients showed widespread morphology atrophy in DMN, suggesting that, despite the absence of a cerebral infarction, ischemic injury may induce structural abnormalities and eventually contribute to functional impairments in TIA patients. Our results may provide a valuable basis for the pathophysiological mechanism related to the cognitive dysfunction of TIA from the view of brain morphology.
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Neurological research · Jan 2015
The association of HLA-DRB1 and HLA-DQB1 alleles with genetic susceptibility to multiple sclerosis in the Slovak population.
The aim of the present study was to assess the association between HLA-DRB1 and -DQB1 allele groups with the genetic predisposition to multiple sclerosis (MS) in the Caucasian Central European Slovak population. ⋯ This is the first study performed to analyse the association of HLA-DRB1/DQB1 with susceptibility to MS in Slovakia. The results of our study confirm that HLA class II alleles, genotypes and haplotypes are associated with MS risk.