Journal of neuroscience methods
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J. Neurosci. Methods · Oct 2009
Investigating the depth electrode-brain interface in deep brain stimulation using finite element models with graded complexity in structure and solution.
Deep brain stimulation (DBS) is an increasingly used surgical therapy for a range of neurological disorders involving the long-term electrical stimulation of various regions of the human brain in a disorder specific manner. Despite being used for the last 20 years, the underlying mechanisms are still not known, and disputed. In particular, when the electrodes are implanted into the human brain, an interface is created with changing biophysical properties which may impact on stimulation. ⋯ However, the frequency-dependent models are necessary as the waveform shaping has a major influence on the activation of neuronal fibres. We also investigate anatomical effects on the electric field, by taking specific account of the ventricular system in the human brain. Taken together, these models allow us to visualise the static, dynamic and target specific properties of the DBS-induced field in the surrounding brain regions.