Journal of neuroscience methods
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J. Neurosci. Methods · Dec 2019
The Quasi-uniform assumption for Spinal Cord Stimulation translational research.
Quasi-uniform assumption is a general theory that postulates local electric field predicts neuronal activation. Computational current flow model of spinal cord stimulation (SCS) of humans and animal models inform how the quasi-uniform assumption can support scaling neuromodulation dose between humans and translational animal. ⋯ Inter-species reproduction of the electric field profile across the entire surface of neuron populations is intractable. Approximating quasi-uniform electric field in a ROI is a rational step to translational scaling.
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J. Neurosci. Methods · Dec 2019
A novel mouse model of contralateral C7 transfer via the pretracheal route: A feasibility study.
Contralateral seventh cervical nerve transfer (contralateral C7 transfer) is a novel treatment for patients with spastic paralysis, including stroke and traumatic brain injury. However, little is known on changes in plasticity that occur in the intact hemisphere after C7 transfer. An appropriate surgical model is required. ⋯ This paper describes a simple, reproducible, and effective mouse model of contralateral C7 transfer for studying brain plasticity and exploring potential new therapies after unilateral cerebral injury.
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J. Neurosci. Methods · Nov 2019
Multi-view learning-based data proliferator for boosting classification using highly imbalanced classes.
Multi-view data representation learning explores the relationship between the views and provides rich complementary information that can improve computer-aided diagnosis. Specifically, existing machine learning methods devised to automate neurological disorder diagnosis using brain data provided new insights into how a particular disorder such as autism spectrum disorder (ASD) alters the brain construct. However, the performance of machine learning methods highly depends on the size of the training samples from both classes. In a real-world clinical setting, such medical data is very expensive and challenging to collect, might (i) suffer from several limitations such as imbalanced classes and (ii) have non-heterogeneous distribution when derived from multi-view brain representations. ⋯ Overall, MV-LEAP achieved the best classification results in comparison with baseline data synthesis methods.
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J. Neurosci. Methods · Jul 2019
Development of a traumatic cervical dislocation spinal cord injury model with residual compression in the rat.
Preclinical spinal cord injury models do not represent the wide range of biomechanical factors seen in human injuries, such as spinal level, injury mechanism, velocity of spinal cord impact, and residual compression. These factors may be responsible for differences observed between experimental and clinical study results, especially related to the controversial issue of timing of surgical decompression. ⋯ This study has validated several novel procedural approaches and injury parameters, and provided critical details to implement in the development of a traumatic cervical dislocation SCI model with residual compression.
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J. Neurosci. Methods · May 2019
Comparative StudyLong term reliability of nociceptive withdrawal reflex thresholds.
The nociceptive withdrawal reflex (NWR) is a polysynaptic spinal reflex protecting the body from harmful stimuli. Two different methods to assess its' threshold (NWR-T) have been part of clinical trials concerning the evaluation of the nociceptive system in the human body. NWR-T's are gathered by stimulation at the sole of the foot and over the sural pathway. Consequently, EMG analyzes the muscle activity over the biceps femoris and tibialis anterior muscle. Past studies favor stimulation at the sole of the foot. ⋯ The NWR-T upholds reliable measurements over a longer period of time and seems to be a stable measure for pain condition. Reliability estimations, EMG recordings, and subject's rating show stimulation at the sole of the foot could be the better choice.