Journal of inorganic biochemistry
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A reactive Cr(IV) ester was synthesized from a reaction of CrO3 with 2,4-dimethyl-2,4-pentanediol as verified by electron spin resonance (ESR) and magnetic susceptibility measurements. ESR spin trapping studies demonstrate that the Cr(IV) ester is capable of generating hydroxyl free radical (. OH) through a Fenton-like mechanism (Cr(IV)+H2O2-->Cr(V)+. ⋯ The results demonstrate that Cr(IV) and its generated. OH radicals are capable of damaging DNA. Moreover, in comparison with Cr(V), Cr(IV) is a more potent DNA damaging agent.