Journal of affective disorders
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Comparative Study
The treatment of depression in UK general practice: selective serotonin reuptake inhibitors and tricyclic antidepressants compared.
Antidepressants are commonly prescribed by general practitioners as treatment for depression. Controversy exists as to the effectiveness in everyday use of the older tricyclic antidepressants (TCAs) when compared to the newer selective serotonin reuptake inhibitors (SSRIs). ⋯ General practitioners should prescribe a therapeutic dose of antidepressant for a recognised therapeutic period to ensure that patients with depression receive the most effective treatment.