Journal of affective disorders
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Meta Analysis
Duloxetine in the treatment of major depressive disorder: comparisons of safety and tolerability in male and female patients.
While some studies have suggested sex differences in the efficacy of antidepressant medications, there have been few investigations into potential sex differences related to safety and/or tolerability. Pooled data from double-blind, placebo-controlled studies were utilized to assess the safety and tolerability of duloxetine in the treatment of major depressive disorder (MDD) in male and female patients. ⋯ No evidence of clinically meaningful sex differences in the safety and tolerability of duloxetine were uncovered.