Journal of affective disorders
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Comparative Study
Early influence of the rs4675690 on the neural substrates of sadness.
CREB1 has previously been implicated in mood disorders, suicide, and antidepressant response. There is some evidence that the T allele in rs4675690, a single-nucleotide polymorphism near the CREB1 gene, is involved in the modulation of neural responses to negative stimuli. It is not known whether differential brain activity during negative mood state appears early in life in T allele carriers. ⋯ The different pattern of regional brain activation found here during transient sadness - in children carrying the T allele, compared to those carrying the C allele - might increase later in life susceptibility to emotional dysregulation and depressive symptoms.
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We used functional magnetic resonance imaging (fMRI) to investigate the neural correlates of sadness, the prevailing mood in major depression (MD), in a prospective, well-documented community sample followed since birth. ⋯ The results are consistent with the results of studies in healthy adults and MD patients. The present study suggests that an altered pattern of regional brain responses to sad stimuli, is already present in childhood and might represent vulnerability for MD later in life.
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This study examined the factor structure of two of the most commonly used screening measures of posttraumatic stress disorder and depression in 164 treatment-seeking veterans who served in Operations Enduring Freedom/Iraqi Freedom/New Dawn (OEF/OIF/OND). ⋯ Combat-related posttraumatic stress disorder and depressive symptoms in treatment-seeking OEF/OIF/OND veterans may be better conceptualized by four dimensions of reexperiencing/avoidance, detachment/numbing, hopelessness/depression, and bodily disturbance symptoms. This symptom structure may provide greater utility when examining other outcomes of interest in this population.
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To describe the prevalence of anxiety, depression and comorbid anxiety-depression among adult cancer survivors six months following diagnosis, and identify the individual, disease, health behaviour, psychological and social factors associated with psychological morbidity. ⋯ Although lower than previously reported, psychological morbidity is prevalent six months after a cancer diagnosis and emphasises the need for routine psychosocial assessment throughout the cancer trajectory to identify those at increased risk or in need of immediate intervention. Physical activity, smoking cessation and coping skills training interventions warrant further exploration.
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This study examined depressive symptoms in bereaved children and adolescents two months after the death of a parent. ⋯ The death of a parent is a risk factor for depressive symptoms and depressive episodes in children and adolescents two months after the death.