Journal of affective disorders
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The neural basis of Major Depressive Disorder (MDD) which is a clinical syndrome characterized by emotional and cognitive impairments is poorly understood. Accumulating evidence has suggested that the insula is an important substrate underlying the mechanism of MDD. This study aimed to examine the disrupted resting-state brain regional function in insula and to further investigate the associated resting-state functional connectivity (rs-FC) of insula underlie the MDD in adolescents and young adults. ⋯ This study highlights the regional/network interaction abnormalities of insula in adolescents and young adults with MDD, and could provide further insight into understanding the neural pathomechanism of MDD in young patients.
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Limited published research has examined the relationships of coping styles and sleep quality with anxiety symptoms in Chinese school adolescents. We aimed to explore the effect of coping styles and sleep quality on anxiety symptoms. Furthermore, we investigated the interactions of coping styles and sleep quality with anxiety symptoms. ⋯ The results of our study showed a higher prevalence of anxiety symptoms compared with the result of a previous study in Chinese school adolescents. Negative coping style and poor sleep quality were associated with an increased prevalence of anxiety symptoms, whereas positive coping style was related to a decreased prevalence of anxiety symptoms. Sleep quality was a mediating factor between negative coping style and anxiety symptoms.
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Maternal pre- and postnatal psychological distress, such as anxiety and depression, may negatively affect mother-infant interaction quality. However, more information is needed on the role of specific types and timings of pre- and postnatal distress symptoms on mother-infant interaction. Research on the role of maternal anxiety is especially scarce. ⋯ Prenatal anxiety and postnatal depressive symptoms may each have unique effects on the different areas of mother-infant interaction, suggesting the need to develop more targeted interventions for mothers with different symptom profiles and timings. Prenatally anxious mothers could potentially benefit from early interventions decreasing stress and anxiety symptoms and specifically promoting their ability to read infant cues appropriately. Infants of postnatally depressed mothers may need interventions where both members of the dyad receive help.