Journal of affective disorders
-
The high recurrence of major depressive disorder (MDD) may derive from underlying state-independent structural alterations. ⋯ Left precentral gyrus CT and left SFG gyrification alterations may represent state-independent alterations in MDD.
-
Depression and anxiety are prevalent psychiatric disorders that carry significant morbidity. Pharmacological and psychosocial interventions are used to manage these conditions, but their efficacy is limited. Recent interest into the use of psychedelic-assisted therapy using ayahuasca, psilocybin or lysergic acid diethylamide (LSD) may be a promising alternative for patients unresponsive to traditional treatments. This review aims to determine the efficacy and tolerability of psychedelics in the management of resistant depression. ⋯ Though further evidence is required, psychedelics appear to be effective in significantly reducing symptoms of depression and anxiety and are well-tolerated.