Journal of the American Academy of Dermatology
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J. Am. Acad. Dermatol. · Jul 1986
Case ReportsOral acyclovir for the prevention of herpes-associated erythema multiforme.
Herpes simplex virus is the single most common precipitator of erythema multiforme. Typically, erythema multiforme lesions appear 10 to 14 days after a recurrent herpes simplex virus infection and attacks can be disabling when they occur at frequent intervals. ⋯ Four patients were treated with a maintenance dose of acyclovir for periods ranging from 10 to 26 months; there were no significant side effects from the drug and only one recurrence of erythema multiforme. Oral acyclovir may become the treatment of choice for herpes-associated erythema multiforme.