Journal of the American Academy of Dermatology
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A 27-year-old woman with active but stable myasthenia gravis developed pemphigus while she was pregnant. Therapeutic abortion performed for personal reasons was followed by clinical and serologic improvement in her immunobullous disease. ⋯ As with another immunobullous disease, herpes gestationis (bullous pemphigoid of pregnancy), hormonal factors appear to induce pemphigus. Although myasthenia gravis and pemphigus have been reported during pregnancy, this is the first instance of coexisting myasthenia gravis and pemphigus in a pregnant woman.
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Perforating pseudoxanthoma elasticum is a rare disorder that can occur in skin lesions associated with hereditary pseudoxanthoma elasticum and as a localized acquired cutaneous form. The localized lesion usually occurs in a periumbilical location in obese, multiparous black women. Here we report an additional case of periumbilical perforating pseudoxanthoma elasticum and discuss its potential relationship to systemic disease (hereditary pseudoxanthoma elasticum).