Journal of the American Academy of Dermatology
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J. Am. Acad. Dermatol. · Nov 1994
Case ReportsLinear IgA bullous dermatosis with autoantibodies to a 290 kd antigen of anchoring fibrils.
We describe a patient with a papulovesicular eruption associated with scarring and severe mucosal lesions that led to blindness. Direct immunofluorescence showed linear IgA deposits at the dermoepidermal junction. ⋯ Direct immunoelectron microscopy showed the IgA deposits to be associated with anchoring fibrils, whereas with Western blot analysis the patient's serum reacted with a 290 kd dermal antigen. On the basis of these findings, we suggest that our case may represent a form of IgA-mediated epidermolysis bullosa acquisita.