Journal of the American Academy of Dermatology
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J. Am. Acad. Dermatol. · Oct 1999
Clinical TrialEfficacy and safety of naltrexone, an oral opiate receptor antagonist, in the treatment of pruritus in internal and dermatological diseases.
The perception of pruritus is modified by endogenous opiates via central opiate receptors in a histamine-independent manner. ⋯ The study suggests that oral opiate antagonists might be a well-tolerated and effective therapy for pruritic symptoms in many diseases.