Journal of the American Academy of Dermatology
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J. Am. Acad. Dermatol. · Mar 1999
Plasmapheresis as an adjunct treatment in toxic epidermal necrolysis.
Toxic epidermal necrolysis (TEN) is a severe, progressive disease characterized by the sudden onset of skin necrosis. It is frequently associated with systemic involvement and has a high rate of morbidity and mortality. Standard therapy includes meticulous wound care, fluid replacement, and nutritional support in an intensive care setting. ⋯ Plasmapheresis is a safe intervention in extremely ill TEN patients and may reduce the mortality in this severe disease. Prospective studies are needed to further define its usefulness.