Journal of the American Academy of Dermatology
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J. Am. Acad. Dermatol. · Aug 2000
Case ReportsThe sign of Leser-Trélat in a case of adenocarcinoma of the lung.
This is what we believe to be the first report of the sign of Leser-Trélat in association with occult adenocarcinoma of the lung. The sign of Leser-Trélat is proposed as a sign of possible occult malignancy, despite various suggestions to the contrary. ⋯ In addition, we suggest a refinement of the definition of the sign of Leser-Trélat and discuss the use of "sign of Leser-Trélat" and "syndrome of Leser-Trélat" in relation to physical findings. All patients with the sign of Leser-Trélat should undergo a thorough evaluation for occult malignancy.
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J. Am. Acad. Dermatol. · Aug 2000
Case ReportsAll-trans-retinoic acid-induced scrotal ulcerations in a patient with acute promyelocytic leukemia.
Induction therapy with all-trans -retinoic acid has been shown to improve the outcome of patients with acute promyelocytic leukemia, although some side effects occur. Dry skin and lips are among the most common cutaneous side effects. We report a case of scrotal ulcerations induced by all-trans -retinoic acid in an American patient; to our knowledge this is the first such case reported.