Journal of the American Academy of Dermatology
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J. Am. Acad. Dermatol. · Mar 2007
Tryptase detection in bone-marrow blood: a new diagnostic tool in systemic mastocytosis.
The condition mastocytosis includes a heterogenous group of disorders that are characterized by abnormal growth and accumulation of mast cells. The detection of serum tryptase, an essential mast cell enzyme, is a widely used tool in the diagnosis of mastocytosis. The diagnosis of systemic mastocytosis is substantially based on the histologic examination of bone-marrow biopsy specimens. ⋯ Our results indicate that the measurement of tryptase in bone-marrow blood is a new, sensitive marker of the mast cell burden in bone marrow of patients with systemic mastocytosis.