Journal of the American Academy of Dermatology
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J. Am. Acad. Dermatol. · Apr 2013
Comparative StudyNodular melanoma: a distinct clinical entity and the largest contributor to melanoma deaths in Victoria, Australia.
There is a growing body of evidence that nodular melanoma (NM), because of its association with increased growth rate and thickness at diagnosis, accounts for a substantial proportion of melanoma deaths. ⋯ The incidence of thick melanomas continues to increase. Nodular melanoma is clinically distinct and the predominant contributor to melanoma-related deaths, representing a public health challenge in reducing skin cancer mortality.
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J. Am. Acad. Dermatol. · Apr 2013
ReviewGeriatric dermatology: Part I. Geriatric pharmacology for the dermatologist.
Issues related to prescribing dermatologic drugs in the elderly are less recognized than age-related skin findings. This is related in part to the lack of a standardized residency training curriculum in geriatric dermatology. ⋯ These changes include volume of distribution, renal function, liver toxicity from interactions of commonly prescribed drugs, and medications that can decompensate cognition in the older patient population. We outline seven prescribing principles related to older dermatology patients, including useful strategies to reduce polypharmacy and improve drug adherence, using an evidence-based approach whenever possible.