Journal of the American Academy of Dermatology
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J. Am. Acad. Dermatol. · Dec 2004
Multicenter StudySensitivity and specificity of reflectance-mode confocal microscopy for in vivo diagnosis of basal cell carcinoma: a multicenter study.
The current standard diagnostic procedure for basal cell carcinoma (BCC) is histologic examination after invasive biopsy. Reflectance-mode confocal microscopy (RCM) offers noninvasive high-resolution imaging of human skin in vivo. ⋯ RCM offers a sensitive and specific tool for the noninvasive diagnosis of BCC in vivo.
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J. Am. Acad. Dermatol. · Dec 2004
Pruritus, pain, and small nerve fiber function in keloids: a controlled study.
Keloid scars can itch and hurt, but little is known about the characteristics of these symptoms in keloids. Because itch and pain are carried by small nerve fibers, abnormal function of these fibers could be an explanation for such phenomena. ⋯ Itch and pain are common presentations in keloids and are associated with abnormalities in small nerve fiber function, suggesting a small nerve fiber neuropathy.
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J. Am. Acad. Dermatol. · Nov 2004
Randomized Controlled Trial Multicenter Study Clinical TrialPimecrolimus cream 1% in the treatment of intertriginous psoriasis: a double-blind, randomized study.
Inverse psoriasis can be difficult to treat because of the high sensitivity of intertriginous areas to cutaneous side effects, such as irritation and striae. Pimecrolimus, a well-tolerated, nonatrophogenic, skin-selective inflammatory cytokine inhibitor, has been shown to be effective in the treatment of psoriasis when applied topically under occlusion. ⋯ Pimecrolimus cream 1% is an effective treatment for inverse psoriasis with a rapid onset of action, and is safe and well-tolerated.
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Advances in our understanding of molecular genetics bring about unique challenges in our ability to practice molecular medicine. With the availability of commercial testing for various genetic cancer syndromes, including hereditary melanoma, specific issues regarding its use and limitations require attention before full translation of this tool into the clinical setting.