Clinics in chest medicine
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Delirium is a frequent complication in older patients in the ICU and often persists beyond their ICU stay. Delirium in older persons in the ICU is a dynamic and complex process. ⋯ Given the high rates of delirium in the ICU that range from 50% to 80% (see references [27, 28, 34]), future studies are urgently needed to examine risk factors for delirium in the ICU setting, such as examining the impact of psychoactive medication use on delirium rates and persistence in the ICU setting. Moreover, studies that examine the impact of delirium prevention in the ICU on rates of delirium, duration and persistence of delirium, and long-term cognitive and functional outcomes post-ICU stay are greatly needed.
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The clinical spectrum of sepsis, severe sepsis, and septic shock is responsible for a growing number of deaths and excessive health care expenditures. Until recently, despite multiple clinical trials, no intervention provided a beneficial outcome in septic patients. Within the last 2 years, studies that involved drotrecogin alfa (activated), corticosteroid therapy, and early goal-directed therapy showed efficacy in those with severe sepsis and septic shock. These results have provided optimism for reducing sepsis-related mortality.
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The recent movement toward standardization of critical care practice is associated with a growth in the use of guidelines and protocols. Although complex, the process of guideline development, implementation, evaluation, and maintenance can be systematic. Guideline implementation can improve the processes and outcomes of care; however, guideline adherence represents a major challenge to their success. The quality of the growing number of practice guidelines in critical care is important to assess and several useful instruments are available for this purpose.
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Shock is an emergency that requires continuous bedside evaluation, resuscitation, and re-evaluation. The initial bedside examination allows the clinician to determine whether the patient exhibits a clinical picture that is consistent with hypovolemic, cardiogenic, or vasodilatory shock. The primary survey dictates urgent initial resuscitation that usually consists of intubation, ventilation, and volume support. ⋯ Early shock has a hemodynamic component, which is often easily reversed. Septic shock and prolonged shock from any cause has an inflammatory component, which is not easily reversed and leads to multiple-system organ failure (MSOF) and death. Success in treatment of shock depends on early recognition of shock and the rapid tempo of resuscitation of its hemodynamic component to prevent or minimize the inflammatory component.
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Hemodynamic monitoring is a diagnostic tool. Because hemodynamic monitoring often requires invasive procedures, it can be associated with an increased incidence of untoward events. ⋯ The diagnostic accuracy of preload responsiveness is markedly improved by the use of arterial pulse pressure or stroke volume variation, neither of which require pulmonary arterial catheterization. The field of hemodynamic monitoring is rapidly evolving and will probably continue to evolve at this rapid pace over the next 5 to 10 years as new technologies, information management systems, and our understanding of the pathophysiology of critical illness progresses.