The Journal of infection
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The Journal of infection · Nov 2012
Gene expression profiling reveals the defining features of monocytes from septic patients with compensatory anti-inflammatory response syndrome.
To characterize the expression profiles of genes in purified monocytes from septic patients during systemic inflammatory response syndrome (SIRS) and compensatory anti-inflammatory response syndrome (CARS), and then to investigate the potential mechanism of monocyte deactivation. ⋯ Monocytes from CARS patients exhibited significant changes in mRNA expression of genes associated with phagocytosis, antigen presentation, inflammatory response, cell migration, and apoptosis, which might cause deactivation of monocytes during CARS.