Brain & development
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Brain & development · Mar 2017
Temporal brain metabolite changes in preterm infants with normal development.
Preterm infants are at high risk for developmental delay, epilepsy, and autism spectrum disorders. Some reports have described associations between these conditions and gamma-aminobutyric acid (GABA) dysfunction; however, no study has evaluated temporal changes in GABA in preterm infants. Therefore, we assessed temporal changes in brain metabolites including GABA using single-voxel 3-Tesla (T) proton magnetic resonance spectroscopy (1H-MRS) in preterm infants with normal development. ⋯ Our results provide new information on normative values of brain metabolites in preterm infants.