Brain & development
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Brain & development · Aug 2008
Review Meta AnalysisFactors associated with adverse neurodevelopmental outcomes in infants with congenital heart disease.
To review reported neurodevelopmental outcome data for patients with congenital heart disease, identify risk factors for adverse neurodevelopmental sequelae and summarize potential neuromonitoring strategies that have been described. ⋯ As advances in the medical and surgical management improves survival in patients with CHD, increasing knowledge about neurodevelopmental outcomes and the factors that affect them will provide for strategies to optimize long-term outcome in this high-risk population.
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Brain & development · Aug 2008
Clinical TrialUse of clonidine in children with autism spectrum disorders.
Children with autism spectrum disorders (ASD) often exhibit sleep and behavioral disorders. Treatment of sleep disorders can be difficult in these children. Clonidine, an alpha2-adrenergic receptor agonist, has been shown to be effective in reducing impulsivity, inattention, and hyperactivity, as well as in serving as a sedative for medial procedures. ⋯ Clonidine was effective in reducing sleep initiation latency and night awakening, to a less degree in improving attention deficits hyperactivity, mood instability and aggressiveness in this cohort of 19 children with ASD. The side effects were largely tolerable. Further evaluation with placebo-controlled double-blind clinical trial of clonidine use in ASD will provide more insight into the clinical efficacy and safety of the medicine in ASD.
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Brain & development · Jun 2008
Scale properties of the Japanese version of the Strengths and Difficulties Questionnaire (SDQ): a study of infant and school children in community samples.
The Strengths and Difficulties Questionnaire (SDQ) is a short screening instrument which addresses the positive and negative behavioral attributes of infants, children and adolescents. The SDQ is widely used to evaluate child developmental disabilities, psychological and psychiatric conditions or disorders in Japan. However, we did not have normative data for the Japanese version until now. ⋯ Based on the distributions of SDQ scores observed in the Japanese community sample, recommended bandings identifying normal, borderline, and abnormal (clinical ranges) were defined for each scale, and some gender difference was found in some difficulties and prosocial SDQ scores. After evaluating parent ratings obtained in a community-based sample, the Japanese SDQ was shown to possess favorable psychometric properties. Thus, the Japanese translation of this popular and versatile instrument seems to be approximately as reliable and useful as the original English questionnaire.
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Brain & development · Mar 2008
Case ReportsSimultaneous diffusion-weighted magnetic resonance images and brain blood perfusion scintigraphy for a transient lesion in the splenium of the corpus callosum.
A transient lesion in the splenium of the corpus callosum is a rare disease and its pathogenesis is unclear. We performed simultaneous diffusion-weighted magnetic resonance images and brain blood perfusion scintigraphy for a transient lesion in the splenium of the corpus callosum. ⋯ However, normal blood perfusion was observed on brain blood perfusion scintigraphy. Transient axonal or intramyelinic edema might be a cause of the transient lesion in the splenium of the corpus callosum.
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Brain & development · Feb 2008
Case ReportsSubdural effusion in a CNS involvement of systemic juvenile xanthogranuloma: a case report treated with vinblastin.
Juvenile xanthogranuloma (JXG) is one of the most common non-Langerhans cell histiocytosis in children. Usually cutaneous, there are disseminated forms. However, neurological localization remains exceptional. ⋯ It allowed the regression of skin, lung, and CNS lesions. At age of 11 years, he had not reappearance of the xanthogranuloma. This report emphasizes the possible presentation of xanthogranuloma with subdural effusions, the organs which should be examined in case of disseminated forms and the efficiency of vinblastin.