Methods and findings in experimental and clinical pharmacology
-
Methods Find Exp Clin Pharmacol · Nov 2008
Randomized Controlled Trial Comparative StudyEfficacy of oral paracetamol and ketoprofen for pain management after major orthopedic surgery.
The hypothesis of this study was that oral paracetamol or ketoprofen can reduce opioid consumption and the adverse effects of opioids after major orthopedic surgery. Sixty patients who had elective total hip replacement surgery took part in this double-blind, randomized, placebo-controlled study. The total doses were paracetamol 4 g and ketoprofen 300 mg. ⋯ Patients in the ketoprofen group consumed a mean of 22% less fentanyl (P < 0.05) in a 20-h period than the placebo group, and 28% less than the patients in the paracetamol group (P < 0.05). Oral ketoprofen (300 mg) decreased fentanyl consumption by 22% in the 20-h period immediately following major orthopedic surgery; fentanyl consumption was unaffected by paracetamol (4 g). The frequency of adverse effects was not reduced by using adjunctive nonopioid analgesics.