Methods and findings in experimental and clinical pharmacology
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Methods Find Exp Clin Pharmacol · Apr 2008
Effects of succinylcholine on the recovery of block produced by mivacurium in rats.
This study investigates the effects of succinylcholine on the recovery of neuromuscular blockade produced by mivacurium in rats. In 48 anesthetized animals, the sciatic nerve was prepared and stimulated, and twitches of the flexor digitorum longus muscle were recorded. ⋯ Duration of action of succinylcholine was more prolonged when it was given in the presence of deeper neuromuscular block induced by mivacurium (p < 0.001 in GroupMivSch(25) and p < 0.01 in GroupMivSch(75)). Our results suggest that, in rats, mivacurium administration has a significant potentiating effect on a subsequent succinylcholine-induced neuromuscular block.