Therapeutic drug monitoring
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Case Reports
Quick onset of severe abdominal pain after codeine in an ultrarapid metabolizer of debrisoquine.
The authors describe a 33-year-old woman who experienced severe pain in the epigastrium after codeine intake. This side-effect is consistent with that of morphine. Later, the patient was phenotyped and genotyped as an ultrarapid metabolizer with high capacity to metabolize codeine to morphine.