Journal of clinical gastroenterology
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J. Clin. Gastroenterol. · Mar 2008
Comparative StudyBowel symptoms in nonerosive gastroesophageal reflux disease: nature, prevalence, and relation to acid reflux.
Nonerosive gastroesophageal reflux disease (NERD) patients frequently show features of the irritable bowel syndrome (IBS). ⋯ (1) NERD patients scored significantly higher than controls on all the bowel scales; (2) Bowel symptoms were associated with reflux symptom scores, but not with acid exposure. (3) The presence of IBS features in a large proportion of NERD patients reflects a high prevalence of visceral hypersensitivity that may aggravate acid reflux symptoms.