American journal of epidemiology
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We investigated the differences in cancer incidence between boys and girls. The incidence data for pediatric cancers were retrieved from the International Incidence of Childhood Cancer project (1990-2015). Poisson regression was applied to detect the sex differences in cancer incidence at global and regional levels. ⋯ Significant sex differences were observed in childhood cancers based on global-scale cancer data. The most pronounced disparities were observed mostly in developing countries, highlighting that data registration quality should be improved and that attention is needed for health-care access and service utilization for girls in these regions. Additionally, given the limited exposures to environmental risk factors in children, the differences might be mainly attributable to some endogenous risk factors and warrant further investigations.