Psychiatry research
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Psychiatry research · Dec 2019
Altered resting-state functional connectivity of the insula in individuals with clinical high-risk and patients with first-episode schizophrenia.
Abnormalities in insular functional connectivity have been implicated in many clinical features of schizophrenia. The aim of this study was to determine to what degree such abnormalities occur in individuals with clinical high risk for psychosis (CHR), and whether which is associated with symptom severity. ⋯ Our findings suggest that insular functional dysconnectivity with the sensory cortex may be a system-level neural substrate preceding the onset of psychosis.