Psychiatry research
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Language could be conceptualized as a dynamic system that includes multiple interactive levels (sub-lexical, lexical, sentence, and discourse) and components (phonology, semantics, and syntax). In schizophrenia, abnormalities are observed at all language elements (levels and components) but the dynamic between these elements remains unclear. We hypothesize that the dynamics between language elements in schizophrenia is abnormal and explore how this dynamic is altered. ⋯ Regression coefficients between syntax and both sentence level and discourse level semantics did not differentiate patients from controls. This study indicates that the dynamics between language elements is abnormal in schizophrenia. In patients, top-down flow of linguistic information might be reduced, and the relationship between phonology and semantics but not between syntax and semantics appears to be altered.
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Psychiatry research · May 2014
Facial emotion perception differs in young persons at genetic and clinical high-risk for psychosis.
A large body of literature has documented facial emotion perception impairments in schizophrenia. More recently, emotion perception has been investigated in persons at genetic and clinical high-risk for psychosis. This study compared emotion perception abilities in groups of young persons with schizophrenia, clinical high-risk, genetic risk and healthy controls. ⋯ Groups also differed for differentiation of happy and sad expressions, but differences were mainly between schizophrenia and control groups. Emotion perception impairments are observable in young persons at-risk for psychosis. Preliminary results with clinical high-risk participants, when considered along findings in genetic risk relatives, suggest social cognition abilities to reflect pathophysiological processes involved in risk of schizophrenia.
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Psychiatry research · May 2014
Higher-order semantic processing in formal thought disorder in schizophrenia.
Higher-order semantic impairments and lack of sensitivity to linguistic context have both been implicated in formal thought disorder (FTD) in schizophrenia. Most investigations have focused on comprehension. We investigated the processing of higher-order semantic relations and the role of emotional arousal in FTD patients' linguistic comprehension and production. ⋯ Complexity affected all groups to a similar extent in sense-judgments, but affected FTD patients disproportionately in the repetition task. These results support the view that a lack of sensitivity to context underlies FTD in comprehension and production stages of processing. Patients fail to utilise linguistic context to integrate lexical forms into a global whole and guide their access to lexical targets.
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Psychiatry research · Apr 2014
Lower health related quality of life in U.S. military personnel is associated with service-related disorders and inflammation.
Military personnel who have combat exposures are at increased risk for the service-related disorders of post-traumatic stress disorder (PTSD), depression, sleep disturbances and decreased health related quality of life (HRQOL). Those with a traumatic brain injury (TBI) are at even greater risk. Inflammation is associated with these disorders and may underlie the risk for health declines. ⋯ In a linear regression model, 41% of the relationship between HRQOL and IL-6 concentrations was mediated by PTSD and depression. Military personnel with PTSD and depression are at high risk for lower HRQOL, and higher IL-6 concentrations. Comprehensive treatment is required to address co-occurring service-related disorders in military personnel to promote health and well-being.
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Psychiatry research · Apr 2014
Case ReportsIdiopathic burning mouth syndrome: a common treatment-refractory somatoform condition responsive to ECT.
Somatic symptom disorders are common causes of disability and suffering, and can pose significant management challenges. Idiopathic burning mouth syndrome is a challenging somatic symptom disorder with relatively high prevalence, particularly among post-menopausal women. Here, we present the case of a woman with severe treatment refractory idiopathic burning mouth syndrome and comorbid major depressive disorder, who was successfully treated with bitemporal electroconvulsive therapy. This case highlights the potential effectiveness of electroconvulsive therapy in idiopathic burning mouth syndrome when other treatment options have been exhausted.